This guide contains information about places where you can stop for the night when driving from Spartanburg, South Carolina to Myrtle Beach, South Carolina. Total distance for the trip is around 241 miles with a driving time of approximately 3 hours 50 mins. Cities and towns with hotels that are on the fastest route between Spartanburg and Myrtle Beach are listed below. (Driving times are approximate and will vary with traffic and weather conditions.)